Cytokine gene polymorphisms in lymphoma: Thesis Abstract

Thesis Abstract Several cytokines are known to be involved in the pathogenesis of non-Hodgkin Lymphomas (NHL). Given importance understanding genetic predisposition NHL, this work was designed study impact IL-10 (-1082 G/A; rs1800896 and -819 C/T; rs1800871), IL-6 (-174 G/C; rs1800795) CD38 (184C/G; rs6449182) gene polymorphisms on susceptibility Egyptians NHL. Both loci IL10 were genotyped using polymerase chain reaction- sequence-specific primers (PCR-SSP), IL6 rs1800795 G/C mutagenically separated PCR (MS-PCR) restriction fragment length polymorphism-PCR (RFLP-PCR) used genotype (rs6449182 C/G) 100 Egyptian patients 119 controls. Plasma levels measured enzyme-linked immunosorbent assay (ELISA). An insignificant change (rs1800896 rs1800871) genotypes recorded. GT haplotype significantly elevated.